After having won this year's Bulgarian trophy, Ludogorets entered the second qualifying round of the UEFA Champions League for the 2012-13 season, but lost 3-4 on aggregate, thanks to the goal of the last minute from Dinamo Zagreb.
As Bulgarian champions during the 2012-13 campaign, Ludogorets played in the UEFA Champions League where they made it through the qualifying rounds and then eliminated Slovan Bratislava as well as Partizan on the way to. Ludogorets later lost to Basel at the Play-Offs however, they were able to participate for the UEFA Europa League.
Ludogorets participated within Group B in 2013-14's Europa League. They were unbeaten during the group stage, finishing second in group, with five wins over six games. This included both home and away wins against the renowned PSV as well as Dinamo Zagreb. The only loss was the draw at home 1:1 with Chornomorets Odesa. In the knockout stage, Ludogorets defeated Italian Cup holders Lazio 1:0 away, and then drew 3:3 in their home stadium for an aggregate score of 4:3 but they then lost 0-3 at home, and 0:4 in aggregate in the final against Valencia at the end of the 16th round.
The 2014-2015 UEFA Champions League, Ludogorets were able to win both of their qualifying matches in the 2014-15 UEFA Champions League, in the first against F91 Dudelange of Luxembourg and Partizan. In the play-offs, they beat Steaua Bucuresti to make it to their first group stage. Goalkeeper Vladislav Stoyanov was dismissed after two yellow cards during the last minutes of added time during the second game, after Ludogorets were using all their substitutes. The penalty shootout center-back Cosmin Moti, who had converted one penalty stepped in goal and saved two times to get Ludogorets at 6:5 with penalties.
Ludogorets were introduced in the 2014-2015 Champions League group phase on 16 September 2014, scoring an equalizer of 1:1 in a game against Liverpool at 90 minutes, scored through Dani Abalo, but in the end, they lost by a score of 1:2 because the goalkeeper who was signed by the club's new owner Milan Borjan gave away a penalty for a foul committed by Javier Manquillo. Steven Gerrard converted, giving Liverpool the win. Ludogorets made their debut at home during the 2014-15 Champions League group phase on 1 October 2014. They scored a spectacular score in the sixth minutes by the forward Marcelinho in a match against Real Madrid, but in a final loss of 1:2. In this game, Cristiano Ronaldo took two penalties. The first could not be saved by the goalkeeper Vladislav Stoyanov. The second goal was scored to earn an equalizer of 1:1. On October 22, 2014 Yordan Minev netted his debut goal with Ludogorets with a vital late winning goal in a 1:0 win at home against Basel during the first round of the Champions League. On the 26th of November, 2014 Dani Abalo scored in the third minute. Georgi Terziev put in his debut strike in the 90th minute of the game, getting a 2:2 draw against Liverpool which resulted in a 2:2 draw.
Ludogorets were awarded their 4th consecutive A Group title, but were sacked by a number of key players of the squad towards the end their season. Georgi Dermendziev was also replaced by Portuguese coach Bruno Ribeiro. The last changes led to Ludogorets losing in the 2nd round of qualifying for the 15-16 UEFA Champions League by the unbeaten Moldovan champions Milsami Orhei.
With Georgi Dermendzhiev back at head of the team in the 2017 Champions League, Ludogorets won the qualifying matches with Mladost the Podgorica team and Red Star Belgrade respectively, and then won the play-off match against Viktoria Plzen. They eventually were the very first Bulgarian team to be twice qualified to play in the first group phase of the competition. The group phase was where Ludogorets had two draw with Basel and one draw against Paris Saint-Germain, which were enough to guarantee them third position and an entry into the knockout phase in the 2016-17 UEFA Europa League. Ludogorets however were forced to withdraw from the competition following their inability to defeat Copenhagen with a first defeat at home of 1:2 and a draw of 0:0 away.
Ludogorets were not able to make it into the groups in the following two seasons of the Champion League, but however they were able to make it into the groups of Europa League. The 2017-18 campaign, they were second after Braga defeating Istanbul Basaksehir and 1899 Hoffenheim after which they lost two matches against Milan in the round of 32.
In 2019-20 the team were defeated from the competition by Ferencvaros in the initial Champions League qualifying round, however, they made it into the stage group of Europa League, following successful games in the group stage against Valur, The New Saints and Maribor in the qualifying round. Ludogorets were drawn once more together with Ferencvaros in the group stage, alongside CSKA Moscow and Spanish club Espanyol. A 5-1 victory at home in the match against CSKA Moscow was followed-up by winning 3-0 away against Ferencvaros. They were defeated twice by Espanyol in the home game, losing 1-0 and 6-0 away, however they ended up second after two 1-1 draws against CSKA and Ferencvaros in the end, being able to qualify for the knockout phase.
