Prior to 2000, there was discord within the players that eventually led to parliamentary as well as executive intervention to settle disputes between two members of the squad, Abedi Pele and Tony Yeboah in the latter part of the 1990s, could be a factor in the squad's inability to replicate the success of the national teams for underage players in the latter part of the 1990s, but a new group comprised of Black Stars players who went to the 2001 FIFA World Youth Championship final were the mainstay of the team in the 2002 African Cup of Nations, and they were undefeated for the entire year in 2005, and made it to the semifinals at the 2006 FIFA World Cup, the first time that the team reached the international stage of the competition. They Black Stars started by succumbing to a 2-0 loss to the eventual champions Italy and then victories against Italy (2-0) and the Czech Republic (2-0) and the United States (2-1) saw them through to the second round which they lost the match 3-0 to Brazil.
The year 2008 saw Ghana was able to achieve a score of 14 on the FIFA Men's World Ranking. Under the direction of head coach Milovan Rajevac the Black Stars went on to attain a 100% record during their qualifying campaign by winning the group and being the very first African team to be selected for 2010's FIFA World Cup. The final game of the tournament was played in Ghana. the team played in Group D along with Germany, Serbia and Australia. Ghana got to in the 16th round, where they faced with the United States, winning 2-1 in extra time, becoming the 3rd African nation to make it to the World Cup quarter-finals. Ghana then fell to Uruguay through a penalty shootout during the quarterfinals in the quarter-finals, after they missed the penalty kick in extra time. What would be the goal to take Ghana into the semifinals was stopped by the deliberate handball of Luis Suarez which was then rewarded with the yellow card due to the actions of his.
In 2013, Ghana became the first team in Africa that has reached four semi-finals in a row of the CAF Africa Cup of Nations twice, in 1963 and 1970 , as well as between 2008 and 2013.
Ghana was highly ranked by FIFA to begin their qualification for World Cup in 2014. World Cup in the Second round. They were crowned the winners of their group and then in the next round they qualified to play in the 2014 World Cup finals in November 2013 when they beat Egypt 7-3, resulting in a play-off that was two legs. Ghana was a part of the group G to play in the World Cup finals in which they were to play Germany, Portugal, and the United States. It was the World Cup finals ended up disappointed due to the fact that Ghana was eliminated during the group stage, without winning a game and issues with poor planning and payments bonuses as the primary reason for their ineffective performance (although they managed to draw an 2-2 draw against the eventual winners Germany). Ghana had the distinction of being the only nation not to lose to Germany during the tournament.
Following this year's World Cup, Ghana slowly began to slowly enter a phase of decline. The last section of their glorious time was written in their 2015 Africa Cup of Nations, in which they Black Stars handily reached the final again but were unable to claim the trophy due to penalties against Ivory Coast. In 2017, their Africa Cup of Nations campaign concluded with a fourth-place finish - the third time in the four previous editions of the tournament they were unable to make an impression in qualifying in the qualifiers for 2018's World Cup, finishing behind Egypt and Uganda in their final group. In the 2019 Africa Cup of Nations in the United States, the Black Stars once again couldn't recreate their winning ways and were defeated from the tournament by Tunisia at the end of the 16th round. The following year, Rajevac returned in the hope of bringing back Ghana's glory of the past however, the team sank to an all-time low in the 2021 Africa Cup of Nations, in which they failed to beat a single game and fell to newcomers the Comoros after receiving an Andre Ayew red-card to be at the bottom of their group, and fail to advance past the stage of group play for the first time since 2006.
In spite of having the Africa Cup of Nations being unsuccessful, Ghana drew 0-0 vs Nigeria and then drew 1-1 against Nigeria to be eligible to host the 2022 FIFA World Cup on the away goals rule.